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The transgenic construct consisted of a 3.6 kb fragment of the Trpv5 promoter inserted upstream of the cre recombinase coding region. This construct was insulated by a chicken lysozyme 5' matrix attachment region inserted in front of the Trpv5 promoter. Mice were generated by injecting the construct into male pronuclei of B6D2F2 zygotes. Founder line information was not available. Transgenic mice were validated by PCR and immunoblotting with a cre antibody. Recombinase activity was assessed in offspring from crosses of cre transgenics with a floxed Aqp2 line. (J:168534)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
