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EN
Four nucleotides in exon 6 were modified (CgAgttggGgaT to TgCgttggAgaC) to encode an Arginine to Cysteine change of codon 163 as well as to generate a new BsmBI restriction site. In addition, a floxed neomycin cytosine deaminase cassette was inserted in the EagI site in intron 6. Germline deletion of the selection cassette was subsequently accomplished in the germ line by breeding to Alp1tm1(cre)Nagy mice. (J:168222)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
