A floxed PGK-neomycin selection cassette in reverse orientation was inserted in intron 1 and a third loxP site was placed in intron 3. The selection cassette was subsequently removed from properly targeted mice by crossing to transgenic mice carrying Tg(EIIa-cre)C5379Lmgd. (J:167543)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count