Alternative exon 1, including the second alternative promoter P2 upstream of it (Rr145), was replaced with a lacZ-neo cassette via homologous recombination. Real-time PCR analysis showed reduced total transcripts throughout development. However, no reduction in total protein level was detected during development. (J:167738)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Insertion, Intragenic deletion
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count