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A loxP site was inserted just upstream of exon 2 (containing the ATG start codon). A floxed neomycin resistance cassette was also inserted in intron 3. The resistance cassette was removed prior to blastocyst injection, presumably by transient cre excision. This left exons 2 and 3 flanked by loxP sites. Miced with this floxed allele were then crossed to mice carrying a Zp3-cre transgene to produce the deleted allele. (J:167430)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
