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The BAC RP23-20N4 containing the entire Spo11 locus (including 188kb of sequence upstream of the initiation codon and 57kb downstream of the stop codon) was engineered by homologous recombination to insert an IRES-cre-(Frt-flanked) neo fragment immediately downstream of the stop codon. The neo was subsequently removed by Flp in bacteria. The modified BAC was injected into the pronuclei of fertilized eggs. Two named lines, D5 and H9, were generated and studied further. (J:166888)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
