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A cDNA encoding the human PML-RARA fusion with nucleotide substitution resulting in the amino acid substitutions of arginine for valine at positions 420 and 432 (V420 and V423R) was inserted into the 5'UTR along with a floxed neo cassette. Cre-mediated recombination removed the neo cassette. The amino acid substitutions generate a protease cleavage-resistant PML-RARA product. (J:166479)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
