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A floxed neomycin resistance cassette in reverse orientation was inserted in intron 1. Mutations were inserted in exon 2 causing an aspartic acid to alanine change at codon 22 (D22A) and arginine to alanine changes at codons 24 and 102 (R24A, R102A). An additional mutation in exon 3 changes codon 117 from arginine to alanine (R117A). All four mutated amino acids are in the extracellular domain of the protein. The selection cassette was subsequently removed by cre excision. (J:166147)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
