Kcnv2^{tm1(KOMP)Wtsi}

The L1L2_Del_BactPneo_FFL cassette was inserted at position 27299497 of Chromosome 19 upstream of exon 1 (Build GRCm39). The cassette is composed of an FRT site followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a loxP site. A second loxP site is inserted downstream of exon 1 at position 27398917. Exon 1 is thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. Further information on targeting strategies used for this and other KOMP alleles can be found at http://www.knockoutmouse.org/about/targeting-strategies. (J:148605)