Three consecutive TEV protease recognition sites with a novel MfeI restriction site were introduced between amino acids S274 and P275 in exon 10. A floxed puro cassette was inserted downstream of exon 11. Cre mediated recombination removed the puro cassette. (J:166151)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count