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The human ITGAM promoter drives expression of the Herpes Simplex Virus thymidine kinse gene. All macrophage-containing organs, including spleen, lung and brain, showed sustained expression of the HSVTK transgene. Transgene expression within the CNS was present in microglial cells but not in astrocytes. Administration of gancyclovir for 5-6 days results in the ablation of ITGAM-expressing cells. Line 618 was also created. (J:96037)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
