Log In|Sign Up
EN
A 2.1-kb genomic fragment of the 5'-flanking region/promoter of the mouse Keratin 19 gene drives expression of the full-length human K-ras gene with a point mutation in codon 12 that alters a Gly residue to a Val in the encoded protein. An intronic fragment from the rabbit beta-globin gene was inserted between the promoter and mutated KRAS gene to enhance gene expression. In addition to line A, lines B and C were also created. (J:83092)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
