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A targeting vector was designed to insert a loxP site upstream of the initiation site of the Epsin 3 (Epn3) gene. A frt-flanked neomycin resistance (neo) cassette, followed by a second loxP site, was placed downstream of exon 9. Cre mediated recombination deleted exons 1 through 9 and the neo. The absence of protein expression was confirmed by immunohistochemistry on parietal cells of the gastric glands. (J:167134)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
