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A BAC containing the GATA3 locus was engineered so that the first exon of the gene was replaced with the coding sequence for EGFP. An frt-flanked kanamycin resistance gene driven by the prokaryotic EM7 promoter was used for selection of correctly recombined colonies. The selection cassette was subsequently removed by flp recombinase in bacteria. The 180 kb final BAC was injected into pronuclei, generating four founder lines. One line was selcected for further analysis. No line numbers were specified in the reference. (J:164670)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
