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Transgenic mice were generated from a BAC in which exon 1 of the Foxn4 locus had been replaced with the coding sequence of codon-improved cre (icre) by homologou recombination. An frt-flanked selection cassette (kanamycin-resistance gene driven by the prokaryotic EM7 promoter) followed the icre sequence and was excised by Flp-recombination in bacteria during recombineering. Three founder lines were generated by pronuclear injection of the final 150 kb construct, with the line providing the most robust combination was selected for further study. No line numbers were specified in the reference. (J:164670)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
