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Exon 4 was replaced with one in which nucleotide substitution resulted in the amino acid substitution of alanine for lysine at position 111 (K111A) and a neo cassette. Cre mediated recombination removed the neo cassette. The absence of catalytic activity was confirmed in E11.5 to E12.5 embryo lysates despite confirmed protein expression. (J:165626)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
