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The endogenous 3' UTR sequence was replaced with a cassette composed of a loxP site followed by the 3' UTR of the Fos gene, followed by the neomycin gene, a second loxP site and finally, the 3' UTR of the bovine growth hormone gene. The modified allele expresses the gene at lower levels whereas, after cre excision of the first 3'UTR and the neo cassette, the endogenous gene is over expressed. (J:165111)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
