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The mouse albumin promoter fused to the promoterless genomic H-2Kb gene, in which the signal sequence of the Kb molecule encoded by exon 1 was replaced by the leader sequence (aa 1-60) of the LCMV glycoprotein (GP) encoding the GP33 epitope (aa 33-41). The construct does not encode a functional Kb molecule, since insertion of the LCMV GP fragment leads to a frame shift and a stop codon in the second exon. RT-PCR analysis revealed GP33 transgene expression in the thymus and liver (100-1000x the level of the thymus). (J:162605)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
