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A cellular IRES in the 5' UTR of exon 3, the coding region of exon 3 and part of intron 3 were replaced with a floxed neo cassette and a Runx1 and Mecom fusion cDNA via homologous recombination. The neo cassette was removed by cre mediated recombination. RT_PCR confirmed the expression of the fusion gene from both endogenous promoters. Western blot analysis confirmed expression of the fusion protein. (J:164806)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
