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The 1.0 kb promoter of the Atp4b gene was cloned into a vector upstream of the 1.2 kb cre recombinase coding sequence and a 2.1 kb human growth hormone gene polyadenylation signal. The 4.3 kb construct was linearized and injected into pronuclei of fertilized FVB oocytes. Two founder animals (3 and 5) were obtained that had the transgene integrated into the genome. Analyses of crosses to a reporter line showed cre recombination occurred only in the stomach, detected at P13. Both lines showed the same pattern of recombination. (J:164715)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
