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The human alpha skeletal muscle actin (ACTA1) promoter was used to drive expression of cre recombinase in a transgenic construct. The construct was injected into C57BL/6 zygotes. 14 founders were generated, and two lines were characterized further. Lines A and B were analyzed. Cre expression was observed in skeletal muscle as well as in the heart, with line A exhibiting 40% of the level of cre mRNA detected in skeletal muscle, and line B showing 0.1% of skeletal muscle cre mRNA levels in the heart muscle. (J:164492)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
