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The loxP-flanked exon 2 of Serpina6tm1Mmp, containing the entire protein coding sequence, has been excised by Cre recombinase. Quantitative real-time PCR analysis of liver mRNA detects no transcripts from the targeted gene in homozygous mutant mice and ~50% of wild-type transcript levels in heterozygous mice. Immunoblot analysis of plasma of homozygous mutant, heterozygous and wild-type mice yields confirmatory results for the for the protein. (J:164345)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
