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A mutation of the methionine coding start codon (ATG) for S-COMT to threonine (ACC), corresponding to 'ATG' position +30 in exon2 of Comt gene and a floxed neo cassette in intron 4 were introduced by homologous recombination. The selection cassette was removed by cre mediated recombination. The S-COMT (24 kDa) isoform was absent on western blots of liver extracts, while the MB-COMT was detected. (J:164057)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
