Log In|Sign Up
EN
An FRT flanked neo with a 5' loxP site was inserted upstream of exon 11. A modified exon 11 (exon 11a) was inserted downstream of the endogenous exon. It contains a stop codon at the 5' end and a loxP site at the 3' end. Flp mediated recombination removed the neo cassette leaving exons 11 and 11a floxed. Severely reduced protein expression was confirmed by western blot analysis on skin and heart extracts. This is a hypomorphic allele. (J:163380)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
