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The construct consisted of the 2.1 kb rat glucagon promoter, a loxP-STOP-loxP sequence and the human growth hormone gene (GH1; hGH). (C57BL/6J x CBA/J)F2 zygotes were injected and at least three founder lines were generated and a line with stable and complete transgene expression (i.e. in about 100% of targeted cells) was established. Crosses with cre-expressing animals will excise the STOP signal, resulting in GH1 expression as a tag. (J:78865)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
