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A neo cassette replaced the promoter and exon 1 (which encodes the entire intracellular domain of the Clec1b receptor, including the YxxL motif required to activate Syk, as well as the transcriptional and translational start sites.) Immunoblotting of cell lysate from platelet-rich plasma of heterozygous animals showed that Clec1b protein levels were about 50% of wild-type and levels were undetectable in homozygous mutants. (J:162815)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
