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The coding sequences of (improved) icre and a tamoxifen-inducible estrogen receptor, ERT2, were fused in-frame and put under the control of 2.5 kb NPHS2 (human podocin) promoter region. The icre/ERT2 fragment was followed by the bovine growth hormone polyA (bGHpA) sequence. The linearized construct was microinjected into the pronuclei of fertilized C57BL/6 eggs. Three of four founders successfully transmitted the transgene to their offspring. (J:162633)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
