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A 1.8 kb rat osteocalcin promoter fragment was used to direct expression of a human TGF-beta2 cDNA in osteoblasts. The TGF-beta2 cDNA was modified by two point mutations which changed the cysteines normally found at codons 226 and 228 to serines. Eight founders were produced but only founder lines D4 and D5 where characterized. Homozygotes could not be derived from the D4 founder. (J:105791)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
