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10 kb of genomic mouse Il5 sequences under the control of the dominant control region (DCR) from human CD2 was used for the transgene. This region drives thymocyte and T-cell specific expression. Northern blot analysis confirmed transgene expression in the thymus, Peyer's patches and subcutaneous lymph nodes of transgenic animals. Founders Tg5C1 and Tg5C2 carry 8 and 49 copies of the transgene, respectively, and express 65X and 265X the amount of blood eosinophils of nontransgenic littermates, respectively. The symbol # is used when no line is specified or both lines are pooled. (J:76902)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
