Tg(CD2-Il5)#Ldt

10 kb of genomic mouse Il5 sequences under the control of the dominant control region (DCR) from human CD2 was used for the transgene. This region drives thymocyte and T-cell specific expression. Northern blot analysis confirmed transgene expression in the thymus, Peyer's patches and subcutaneous lymph nodes of transgenic animals. Founders Tg5C1 and Tg5C2 carry 8 and 49 copies of the transgene, respectively, and express 65X and 265X the amount of blood eosinophils of nontransgenic littermates, respectively. The symbol # is used when no line is specified or both lines are pooled. (J:76902)