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The transgene is composed of TRE2, a tetracycline responsive element, the human NRAS coding sequence containing a G to V mutation at codon 12, followed by the EMCV IRES and a truncated human CD2 lacking the intracellular signaling portion of the molecule. Three independent founder lines of transgenic mice were established. (J:101142)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
