One loxP site was inserted in the 3' end of intron 1. An FRT flanked Pgk-neo-PgkTkselection casette was inserted along with a second loxP site 600 bp downstream from exon 7. The FRT flanked selection cassette was removed by transient transfection using an FLPe expression vector. (J:162067)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count