Tg(RP23-326M22)760She

This transgene consists of the C57BL/6J mouse bacterial artificial chromosome (BAC) RP23-326M22 (GenBank id AC096624), which contains the entire coding sequence of the retinoic acid induced 1 (Rai1) gene. The BAC also includes the sterol regulator element binding transcription factor 1 gene (Srebf1; formerly Srebp1) and the 3' end of Tom1l2. Founder line 760 has integrated ~4 copies of the transgene at a single site. Overexpression of Rai1 in the brain and liver was verified by quantitative RT-PCR and western blot analysis. (J:161765)