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These transgenic mice express the human LRRK2 gene with high levels of protein detected, with an expression pattern similar to that of endogenous mouse Lrrk2. The transgene inserted into Chromosome 12. Transgenic mice express human LRRK2 approximately 20-22 fold over the endogenous mouse Lrrk2 level. Line WT1 was generated. (J:161656)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
