A loxP site was inserted into intron 2 and a loxP site flanked neomycin resistance gene cassette into intron 3. HA epitope sequence was added to the the 3' end of the coding region in exon 3. Exon 3 and the neo cassette were removed by cre-mediated recombination. Immunoblots of splenocytes failed to detect any protein. (J:160935)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S/Sv
Targeted
Insertion, Intragenic deletion
--
1
--
6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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