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A 2.95 kb fragment of the 5' UTR of the human PLP gene drives expression of a cDNA encoding for the DM-20 isoform of human PLP. The cDNA is followed by the small tumor (t) antigen splicing signals and early region polyadenylation signal of SV40. This line contains about 70 copies of the transgene. Northern blot analysis detected expression of the transgene in the brain but not in the liver or kidney. Northern blot analysis also indicated a reduction in the expression of the endogenous Plp1 gene. (J:24069, J:162843)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
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PMID
Journal
Year
IF
