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A 1.9 kb fragment of the mouse Mbp promoter (from the pMG2 plasmid) drives expression of a 2.3 kb cDNA fragment encoding rat Pad2. This line contains 15 copies of the transgene. Immunohistochemical analysis indicates increased expression in the white matter tracts of the corpus callosum. Immunoslot blot analysis of whole brain homogenates also indicates increased expression in mice at 2 to 6 months of age. Myelin samples from the central nervous system contain increased levels of MBP citrullination. (J:142650)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
