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The genomic sequence spanning the 3' portion of exon 16 to the 5' portion of exon 17 was replaced. This deletion removed 74 amino acids of the protease domain. This allele is expected to produce a protein lacking protease activity. Reduced expression of a transcript lacking the targeted region was confirmed by QRT-PCR. (J:160248)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
