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This transgene contains a full length human cDNA encoding solute carrier family 2 (facilitated glucose transporter), member 1 (SLC2A1; also called glucose transporter 1, GLUT1) between a modified human beta-actin promoter and the SV40 polyadenylation signal. Western blot analysis demonstrates 3.5-fold nomal levels of glomerular GLUT1 protein in 26 week old mice hemizygous for the transgene. Immunolabeling detects GLUT1 overexpression in glomerular mesagial cells and small vessels, but not in the renal tubules, of the kidney. (J:160943)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
