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This transgene contains a cDNA encoding the viral 40-kDa Tax transactivator protein of human T-lymphotropic virus, type I (HTLV-1; also called human T-cell leukemia virus, type I) under control of the Tet operon (tetO), which comprises seven copies of the tetracycline responsive element (TRE) upstream of the cytomegalovirus minimal promoter. In a bitransgenic mouse also expressing tTA (tet-off) or rtTA (tet-on) from a tissue-specific promoter, Tax is conditionally expressed in the absence or presence, respectively, of tetracycline. (J:102153)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
