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The transgene contains a 3.6 kb human AMH promoter, and a murine Fshr with Asp580His mutation. Line number 14 was used in the study of mRNA and hormone level. mRNA of the transgenes was expressed in the ovaries and testes. The expression level of the transgene was similar to that of the endogenous mFshr in the ovaries. The severity of the abnormalities detected in ovaries, adrenal gland, pituitary gland and mammary gland correlated with the ovarian transgenic expression level. (J:160015)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
