A loxP site was inserted in intron 2 and a floxed neo cassette was inserted in intron 8 via homologous recombination. Western blot analysis indicates a reduction in protein expression in homozygous and heterozygous mice, thus, this is a hypomorphic allele. (J:123288)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count