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This transgene contains the tetracycline responsive element (TRE) driving expression, from a minimal promoter, of a mutant guanine nucleotide-binding protein, alpha q polypeptide (alpha q) in which the arginine at amino acid position 183 has been replaced by cysteine (R183C). This constitutively active mutant protein maintains phospholipase C in an active state. It is expressed in the presence of tTA without tetracycline (tet-off) or in the presence of rtTA and tetracycline (tet-on), (J:94077)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
