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This transgene contains the tetracycline transactivator responsive element (TRE) driving expression, from a minimal promoter, of the catalytic S1 subunit of pertussis toxin, encoded by ptxA. This permits tTA (tet-off) or rtTA (tet-on) to induce expression of PTX-S1, which blocks signaling via the pertussis toxin-sensitive G proteins (Gi and Go). (J:94077)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
