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The rat elastase promoter drives expression of the human interleukin-1beta gene. Expression of the transgene was confirmed in the pancreas by reverse-transcription (RT)-PCR and by enzyme-linked immunosorbent assay (ELISA) measurement of human IL-1beta peptide in pancreatic protein extracts. Expression was not detected in any of the other tissues analyzed, including liver, submaxillary glands, kidney, lung, and spleen. (J:142524)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
