The floxed exon 3 in Ikbkbtm2Mka was removed via cre-mediated recombination by breeding with Tg(Vil-cre)1Mka mice. Although this cre transgene is expressed in the small intestinal epithelial and colon epithelial cells, a small amount of cre recombination occurred in the testis resulting in germline transmission of the exon 3 deleted allele. (J:82995, J:88644)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129/Sv
Targeted
Intragenic deletion
--
1
3
5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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