A floxed neo cassette was inserted upstream of the 599 bp exon (exon 3 or 5 depending on the gene model) and a loxP site was inserted downstream of the exon. Cre mediated recombination removed the neo cassette leaving the exon floxed. (J:159387)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count