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The mouse Tyr promoter was used to drive expression of a Th chimeric minigene composed of a mouse genomic fragment containing exons 1 and 2, rat cDNA containing sequence from exons 2 to 11, and mouse genomic sequence for exons 11 to 13. The Th minigene is deposited in GenBank as AY855842. An IRES element linked the Th construct to Gch1. Six founders were identified. Founder line 6775 contained four copies of the transgene and expressed the highest eye-specific tyrosine hydroxylase levels. (J:105984)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
