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Exon 3' was replaced with a neo cassette by homologous recombination. This targets the delta Np73 isoforms but not TAp73 isoforms. The loss of Np73 isoform mRNA expression was confirmed by quantitative RT-PCR in MEFs and western blot analysis of lung tissue confirmed loss of isoform specific protein expression. Quantitative RT-PCR of liver, testis, and lung confirmed the retention of TAp73 isoform mRNA expression. (J:157905)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
