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The open reading frame of the targeted gene was replaced by nuclear-localized beta-galactosidase (nLacZ; using an SV40 nuclear localization signal) using homologous recombination in a 129-derived embryonic stem (ES) cell line. A LoxP-flanked neomycin selectable marker used for ES cell selection was removed by subsequent crossing to a mouse line expressing germline Cre recombinase. (J:159435, J:189062)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
