Log In|Sign Up
EN
The transgene construct has a loxP-flanked Beta-geo gene driven by the CAG promoter, followed by the SV40 tsA58 large T antigen (cDNA for the SV40 TAg and the 3' portion of tsA58T antigen sequence with the A438V mutation.) In the absence of cre-mediated recombination, Beta-geo is expressed and detected by X-gal staining. Removal of the loxP-flanked Beta-geo results in expression of the tsA58T antigen, leading to temperature-dependent cell-type independent cell proliferation, (J:159206)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
